Polynucleotides are an advanced regenerative skin treatment designed to repair, deeply hydrate, and rejuvenate the skin at a cellular level. Rather than simply masking concerns or creating temporary volume, this innovative treatment works beneath the surface to improve overall skin health and function.

Unlike traditional dermal fillers that primarily add structure or fullness, polynucleotides stimulate your skin’s natural healing and renewal processes. They activate fibroblasts, the cells responsible for producing collagen and elastin encouraging long-term tissue regeneration. The result is stronger, healthier skin with improved elasticity, smoother texture, and enhanced radiance.
Polynucleotides work by directly activating fibroblasts, the cells that produce your skin's own collagen and elastin, rather than simply supplying hydration like a skin booster. That regenerative action is what sets this treatment apart: it aims to improve the underlying health and repair capacity of the skin itself, not just its surface hydration.
DNA-derived fractions are placed into the mid-dermis, where they stimulate fibroblast activity, the cells responsible for producing new collagen and elastin.
Rather than adding structure like a filler, polynucleotides support the skin's own healing and renewal processes, which is why results build gradually and look like healthier skin, not added fullness.
Alongside collagen stimulation, polynucleotides have a soothing effect on inflamed or reactive skin, making them useful for sensitive or compromised skin as well as ageing concerns.
We review your skin's condition, medical history and goals to confirm polynucleotides are the right fit, whether for regeneration, hydration or scar support.
Topical numbing cream is applied where needed and the treatment area is thoroughly cleansed before injections begin.
The polynucleotide solution is delivered into the mid-dermis via a series of fine injections across the treatment area.
You're given aftercare guidance for the first 48 hours and your next session is scheduled as part of your initial course.
Typical initial course length, followed by a maintenance session roughly every six to nine months to sustain results.
General clinical consensus from published polynucleotide research. Course length can vary by concern treated.

Polynucleotides have a strong clinical safety record, with published research reporting no serious adverse effects in the majority of patients. Mild swelling or bruising at the injection site is the most common side effect, and this usually clears within 48 hours.
Skin boosters use hyaluronic acid mainly for hydration. Polynucleotides use DNA-derived fractions to directly activate fibroblasts, supporting the skin's own collagen production and repair processes rather than only adding moisture.
Most formulations are derived from purified DNA fractions, commonly sourced from salmon. They're biocompatible and well tolerated by most patients, though they aren't suitable for anyone with a fish allergy.
The face, under-eye area, neck and scalp can all be treated, with the approach adjusted depending on whether the goal is regeneration, hydration or calming reactive skin.
Most clients start with a course of around three sessions, spaced two to four weeks apart, followed by a maintenance session every six to nine months.
Downtime is minimal. Mild swelling or small bruises at the injection sites are the most common effects, and these typically resolve within 48 hours.
Some hydration improvement can appear within the first week, while the fuller regenerative benefit from new collagen production tends to build gradually across the full course of sessions.
Book a consultation at The Glo Bar in Ruislip and we'll talk through whether polynucleotides are the right fit for your skin.
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